Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation-Reference-Cited by-同舟云学术

Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation

Published:2021-09-09 Issue:19 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Knudson Cory J.¹,Férez Maria¹,Alves-Peixoto Pedro¹²³^ORCID,Erkes Dan A.¹,Melo-Silva Carolina R.¹^ORCID,Tang Lingjuan¹^ORCID,Snyder Christopher M.¹^ORCID,Sigal Luis J.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

2. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal

3. ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal

Abstract

While it is well established that cytotoxic CD4 T cells (CD4-CTLs) directly contribute to viral clearance, it remains unclear how CD4-CTL are induced. We now show that CD4-CTLs require sustained antigen presentation and are induced by CD11c-expressing antigen-presenting cells.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute on Aging

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00566-21

Reference63 articles.

1. Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection

2. Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection