Affiliation:
1. Cancer Research Institute, Sapporo Medical College, Sapporo 060, Japan
Abstract
O antigen mutants were obtained from
Salmonella durban
, a group D
1
organism, by treatment with
N
-methyl-
N′
-nitro-
N
-nitrosoguanidine. Serological studies demonstrated that the mutants lost the O-9 antigen factor of the parent organism but acquired the O-2 factor specific to group A
Salmonella
. Lipopolysaccharides of the mutant strains contained paratose which determines the specificity of O-2 factor. Tyvelose, present in the wild-type lipopolysaccharide, was not found in the mutants. H antigens and other biological characteristics of the mutant strains were the same as those of the wild-type organism. The present finding implies that group A
Salmonella
species might be derived from group D
1
organisms.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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