Affiliation:
1. Department of Bacteriology, Royal Postgraduate Medical School, Ducane Road, London W12 OHS England; Department of Bacteriology, Clinic of Therapeutics, University of Athens, Athens, Greece; and Microbiology Section, Department of Pharmaceutics, The School of Pharmacy University of London, London WC1N 1AX, England
Abstract
Beta (β)-lactamases determined by 29 ampicillin resistance plasmids could be divided into two types. One, TEM-type, was very uniform with respect to substrate specificity but heterogeneous in absolute levels of β-lactamase activity. The TEM-type β-lactamase was determined by R factors of compatibility groups FII, Iα, Iε, N, C, A, T, W, P, L, and X, and by prophage φ Amp. The other type, characterized by the ability to hydrolyze oxacillin, was less common, showed lower absolute levels of activity, and was heterogeneous as regards substrate specificities. Oxacillin-hydrolyzing β-lactamases were determined by R factors of compatibility groups FI, Iα, N, C, and O.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
148 articles.
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