The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from Wuhan-Reference-Cited by-同舟云学术

The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from Wuhan

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Liu Xiang¹²³^ORCID,Mostafavi Helen¹²³^ORCID,Ng Wern Hann¹²³^ORCID,Freitas Joseph R.¹²³,King Nicholas J. C.¹⁴⁵^ORCID,Zaid Ali¹²³^ORCID,Taylor Adam¹²³^ORCID,Mahalingam Suresh¹²³^ORCID

Affiliation:

1. Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

2. Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, Queensland, Australia

3. School of Medical Sciences, Griffith University, Gold Coast, Queensland, Australia

4. The Discipline of Pathology and Bosch Institute, School of Medical Sciences, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia

5. Marie Bashir Institute for Infectious Diseases and Biosecurity, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia

Abstract

SARS-CoV-2 variants, with the threat of increased transmissibility, infectivity, and immune escape, continue to emerge as the COVID-19 pandemic progresses. Detailing the pathogenesis of disease caused by SARS-CoV-2 variants, such as Delta, is essential to better understand the clinical threat caused by emerging variants and associated disease.

Funder

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00683-22

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