TrmB Family Transcription Factor as a Thiol-Based Regulator of Oxidative Stress Response

Author:

Mondragon Paula1,Hwang Sungmin12,Kasirajan Lakshmi13,Oyetoro Rebecca1,Nasthas Angelina1,Winters Emily1,Couto-Rodriguez Ricardo L.1,Schmid Amy24ORCID,Maupin-Furlow Julie A.15ORCID

Affiliation:

1. Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA

2. Department of Biology, Duke University, Durham, North Carolina, USA

3. ICAR-Sugarcane Breeding Institute, Coimbatore, India

4. Center for Genomics and Computational Biology, Duke University, Durham, North Carolina, USA

5. Genetics Institute, University of Florida, Gainesville, Florida, USA

Abstract

TrmB-like proteins, while not yet associated with redox stress, are found in bacteria and widespread in archaea. Here, we expand annotation of a large group of TrmB-like single winged-helix DNA binding domain proteins from diverse archaea to function as thiol-based transcriptional regulators of oxidative stress response.

Funder

National Science Foundation

HHS | National Institutes of Health

U.S. Department of Energy

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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