Dual-Role of Cholesterol‐25‐Hydroxylase in Regulating Hepatitis B Virus Infection and Replication-Reference-Cited by-同舟云学术

Dual-Role of Cholesterol‐25‐Hydroxylase in Regulating Hepatitis B Virus Infection and Replication

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wei Qi¹²,Song Hongxiao¹,Gao Yanli³,Xu Fengchao¹,Xiao Qingfei⁴,Wang Fei¹,Lei Bingxin²,Niu Junqi¹⁵,Gao Pujun⁵,Ma Haichun²,Tan Guangyun¹^ORCID

Affiliation:

1. Center for Pathogen Biology and Infectious Diseases, Department of Immunology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, the First Hospital of Jilin University, Changchun, Jilin, China

2. Department of Anesthesiology, the First Hospital of Jilin University, Changchun, Jilin, China

3. Department of Pediatrics, the First Hospital of Jilin University, Changchun, Jilin, China

4. Department of Nephrology, the First Hospital of Jilin University, Changchun, Jilin, China

5. Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, China

Abstract

The enzymatic product of CH25H, 25-hydroxycholesterol (25HC), has been previously shown to play a critical role in the blockage of the cell-virus fusion in response to viral infection. However, our study indicates a dual role of CH25H in regulating HBV. We find the CH25H-mediated inhibition of HBV replication is independent on its enzyme activity and CH25H binds to HBx and inhibits HBx nucleus translocation. We are interested to find out 25HC promotes HBV infection.

Funder

China Postdoctoral Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00677-22

Reference46 articles.

1. Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities

2. Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival

3. Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol