Penicillin-Binding Protein 1 (PBP1) of Staphylococcus aureus Has Multiple Essential Functions in Cell Division-Reference-Cited by-同舟云学术

Penicillin-Binding Protein 1 (PBP1) of Staphylococcus aureus Has Multiple Essential Functions in Cell Division

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wacnik Katarzyna¹²,Rao Vincenzo A.³,Chen Xinyue²⁴,Lafage Lucia¹²,Pazos Manuel⁵,Booth Simon³,Vollmer Waldemar⁵,Hobbs Jamie K.²⁴,Lewis Richard J.³,Foster Simon J.¹²^ORCID

Affiliation:

1. School of Biosciences, University of Sheffield, Sheffield, United Kingdom

2. The Florey Institute for Host-Pathogen Interactions, University of Sheffield, Sheffield, United Kingdom

3. Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

4. Department of Physics and Astronomy, University of Sheffield, Sheffield, United Kingdom

5. Centre for Bacterial Cell Biology, Bioscience Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

Abstract

Bacterial cell wall peptidoglycan is essential, and its synthesis is the target of clinically important antibiotics such as β-lactams. β-lactams target penicillin-binding proteins (PBPs) that assemble new peptidoglycan from its building blocks. The human pathogen Staphylococcus aureus only has two essential PBPs that can carry out all the functions necessary for growth and division.

Funder

UKRI | Medical Research Council

UK Strategic Priorities Fund

Wellcome Trust

The Florey Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00669-22

Reference76 articles.