Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump-Reference-Cited by-同舟云学术

Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump

Published:2023-06-27 Issue:3 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhang Zhemin¹,Morgan Christopher E.¹,Bonomo Robert A.²^ORCID,Yu Edward W.¹^ORCID

Affiliation:

1. Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

2. Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

Abstract

Klebsiella pneumoniaehas emerged as one of the most problematic and highly antibiotic-resistant pathogens worldwide. It is the second most common causative agent involved in secondary bacterial infection in COVID-19 patients.K. pneumoniaecarbapenemase (KPC)-producingK. pneumoniaeis a major concern in global public health because of the high mortality rate of this infection.

Funder

HHS | NIH | Office of Extramural Research, National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00659-23

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