The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25’s RNA Binding Ability-Reference-Cited by-同舟云学术

The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25’s RNA Binding Ability

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Chiang Cindy¹²,Dvorkin Steve²,Chiang Jessica J.³,Potter Rachel B.²,Gack Michaela U.¹²^ORCID

Affiliation:

1. Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, Florida, USA

2. Department of Microbiology, The University of Chicago, Chicago, Illinois, USA

3. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA

Abstract

The innate immune response is the first line of defense against viral pathogens, and in turn, many viruses have evolved strategies to evade detection by the host’s innate immune surveillance machinery. Investigation of the interplay between viruses and the innate immune response provides valuable insight into potential therapeutic targets against viral infectious diseases.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00620-21

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