Listeria-Vectored Multiantigenic Tuberculosis Vaccine Enhances Protective Immunity against Aerosol Challenge with Virulent Mycobacterium tuberculosis in BCG-Immunized C57BL/6 and BALB/c Mice

Author:

Jia Qingmei1,Masleša-Galić Saša1,Nava Susana1,Horwitz Marcus A.1ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Center for Health Sciences, School of Medicine, University of California—Los Angeles, Los Angeles, California, USA

Abstract

TB, one of the world's most important infectious diseases, afflicts approximately 10 million people and kills approximately 1.5 million people annually. The current vaccine, BCG, developed over a century ago, has been administered to about 5 billion people, mostly in infancy, but is only modestly protective.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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