Critical Residues Involved in the Coassembly of L1 and L2 Capsid Proteins of Human Papillomavirus 16-Reference-Cited by-同舟云学术

Critical Residues Involved in the Coassembly of L1 and L2 Capsid Proteins of Human Papillomavirus 16

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chen Jie¹²,Wang Daning¹²,Wang Zhiping¹²,Wu Kunbao¹²,Wei Shuangping¹²,Chi Xin¹²,Qian Ciying¹²,Xu Yujie¹²,Zhou Lizhi¹²³,Li Yuqian¹²,Zhang Sibo¹²,Li Tingting¹²³,Kong Zhibo¹²³,Wang Yingbin¹²³,Zheng Qingbing¹²³,Yu Hai¹²³,Zhao Qinjian¹²,Zhang Jun¹²³,Xia Ningshao¹²³⁴,Li Shaowei¹²^ORCID,Gu Ying¹²

Affiliation:

1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, Fujian, China

2. National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, Fujian, China

3. Xiang An Biomedicine Laboratory, Xiamen, Fujian, China

4. Research Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen, Fujian, China

Abstract

Over 200 types of HPV have been isolated, with several high-risk types correlated with the occurrence of cervical cancer. The HPV major capsid protein, L1, assembles into a T=7 icosahedral viral shell, and associates with the minor capsid protein, L2, which plays a critical role in the HPV life cycle.

Funder

National Natural Science Foundation of China

Fujian Provincial Health And Education Joint Research Project

Xiamen Key Project in Science and Technology

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01819-22

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1. Human papillomaviruses in the pathogenesis of anogenital cancer