Author:
Saravolatz Louis D.,Pawlak Joan,Johnson Leonard,Bonilla Hector,Saravolatz Louis D.,Fakih Mohamad G.,Fugelli Anders,Olsen Wenche Marie
Abstract
ABSTRACTLTX-109 and eight other antimicrobial agents were evaluated against 155 methicillin-resistantStaphylococcus aureus(MRSA) isolates, including strains resistant to vancomycin and strains with decreased susceptibility to daptomycin and linezolid, by microdilution tests to determine MICs. Time-kill assays were performed against representative MRSA, vancomycin-intermediateS. aureus(VISA), and vancomycin-resistantS. aureus(VRSA) isolates. LTX-109 demonstrated a MIC range of 2 to 4 μg/ml and dose-dependent rapid bactericidal activity againstS. aureus. This activity was not influenced by resistance to other antistaphylococcal agents.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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