Increased Prevalence of G1P[4] Genotype among Children with Rotavirus-Associated Gastroenteritis in Metropolitan Detroit

Author:

Abdel-Haq Nahed M.123,Thomas Robert A.123,Asmar Basim I.12,Zacharova Viera3,Lyman William D.13

Affiliation:

1. Department of Pediatrics, Wayne State University School of Medicine

2. Division of Infectious Diseases, Children's Hospital of Michigan

3. Children's Research Center of Michigan, Wayne State University, Detroit, Michigan 48201

Abstract

ABSTRACT The G and P genotypes of rotavirus stool isolates from 100 children were determined by reverse transcription-PCR and nucleotide sequencing. G1P[4] was the most prevalent genotype(41%), followed by G1P[8] (16%) and G4P[4] (14%). The G genoypes detected were G1 (73%), G4 (17.4%), G9 (6.3%), and G2 (2.8%). The P genotypes were P[4] (71%) and P[8] (29%). Coinfection with more than one G genotype occurred in 12 patients, and coinfection with more than one P genotype occurred in 11 patients.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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4. Estes M. 1996. Rotaviruses and their replication p. 1625-1655. In B. N. Fields D. M. Knipe and P. M. Howley (ed.) Fields virology 3rd ed. vol. 2. Lippincot-Raven Philadelphia Pa.

5. Identification of group A rotavirus gene 4 types by polymerase chain reaction

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