Affiliation:
1. Department of Medicine, Department of Veterans Affairs Medical Center, Brooklyn, New York 11209.
Abstract
Enterococci resistant to ampicillin, vancomycin, and/or aminoglycosides are a growing clinical problem. We studied the in vitro activity of the new fluoroquinolone clinafloxacin (PD 127,391) against 15 clinical isolates of multidrug-resistant Enterococcus faecium. In kill-kinetic studies, clinafloxacin (1 microgram/ml) was bactericidal against 7 of 12 susceptible isolates, although substantial regrowth occurred in 4 isolates at 48 h. The addition of ampicillin (20 micrograms/ml) resulted in bactericidal activity in all 12 isolates, and no regrowth was seen. For three isolates resistant to clinafloxacin, effective killing was not observed at these concentrations of antibiotics. Clinafloxacin with ampicillin shows promising activity against many of these multiply resistant enterococci.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference16 articles.
1. Dorr M. B. C. L. Webb N. Bron and A. B. Vassos. 1991. Single-dose tolerance and pharmacokinetics of CI-960 (PD 127391) in healthy volunteers abstr. 1154. Program Abstr. 31st Intersci. Conf. Antimicrob. Agents Chemother.
2. Identification of Enterococcus species isolated from human infections by a conventional test scheme;Facklam R. R.;J. Clin. Microbiol.,1989
3. In vitro and in vivo activity of ciprofloxacin against enterococci isolated from patients with infective endocarditis;Fernandez-Guerrero M.;Antimicrob. Agents Chemother.,1987
4. Nosocomial outbreak due to Enterococcusfaecium highly resistant to vancomycin, penicillin, and gentamicin;Handwerger S.;Clin. Infect. Dis.,1993
5. A cluster of vancomycinresistant Enterococcus faecium in an intensive care unit;Karanfil L. V.;Infect. Control Hosp. Epidemiol.,1992
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