Abstract
The dimorphic fungus Mucor racemosus exhibited a single-step, inducible resistance to cycloheximide, trichodermin, and amphotericin B. Cells adapted to inhibitory levels of the antibiotics after 12 to 40 h. The adaptation involved all the cells in the population and was not the result of the selection of resistant mutants. Adaptation to one drug provided cross resistance to other, dissimilar drugs. Resistance was lost within several generations of growth in the absence of the inhibitors.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference18 articles.
1. Unstable, non-mutational expression of resistance to the thymidine analogue, trifluorothymidine in CHO cells;Adair G. M.;Mutat. Res.,1979
2. Development of strains of Cyptococcus neoformans resistant to nystatin, amphotericin B, trichomycin and polymyxin B;Bodanhoff J.;Acta Pathol. Microbiol. Scand.,1968
3. Antimicrobial agents. XIX. Detoxification mechanisms of some strains of Candida;Capek A.;Folia Microbiol.,1973
4. Antimicrobial agents. XVIII. Inducible resistance in species of the gen,is Candida;Capek A.;Folia Microbiol.,1972
5. Antimicrobial agents. VI. Antimycotic activity and problems of resistance;Capek A.;Folia Microbiol.,1970
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献