In Chronic Infection, HIV Gag-Specific CD4 + T Cell Receptor Diversity Is Higher than CD8 + T Cell Receptor Diversity and Is Associated with Less HIV Quasispecies Diversity-Reference-Cited by-同舟云学术

In Chronic Infection, HIV Gag-Specific CD4 + T Cell Receptor Diversity Is Higher than CD8 + T Cell Receptor Diversity and Is Associated with Less HIV Quasispecies Diversity

Published:2021-03-25 Issue:8 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pilkinton Mark A.¹,McDonnell Wyatt J.¹,Barnett Louise¹,Chopra Abha²,Gangula Rama¹,White Katie D.¹,Leary Shay²,Currenti Jennifer³,Gaudieri Silvana¹²³,Mallal Simon A.¹²⁴,Kalams Spyros A.¹⁴^ORCID

Affiliation:

1. Vanderbilt University Medical Center, Department of Internal Medicine, Nashville, Tennessee, USA

2. Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia

3. School of Human Sciences, University of Western Australia, Nedlands, Australia

4. Vanderbilt University School of Medicine, Department of Pathology, Microbiology and Immunology, Nashville, Tennessee, USA

Abstract

Human T cells recognize portions of viral proteins bound to host molecules (human leukocyte antigens) on the surface of infected cells. T cells recognize these foreign proteins through their T cell receptors (TCRs), which are formed by the assortment of several available V, D, and J genes to create millions of combinations of unique TCRs.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02380-20

Reference47 articles.

1. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

2. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

3. Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection

4. Limited T Cell Receptor Diversity of HCV-specific T Cell Responses Is Associated with CTL Escape

5. T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection

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