C/EBPbeta is a negative regulator of human papillomavirus type 11 in keratinocytes-Reference-Cited by-同舟云学术

C/EBPbeta is a negative regulator of human papillomavirus type 11 in keratinocytes

Published:1996-07 Issue:7 Volume:70 Page:4839-4844
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wang H¹,Liu K¹,Yuan F¹,Berdichevsky L¹,Taichman L B¹,Auborn K¹

Affiliation:

1. Department of Otolaryngology, Long Island Jewish Medical Center, Long Island Campus of Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.

Abstract

We have evaluated the impact of the CCAAT enhancer-binding protein (C/EBP) transcription factors on human papillomavirus type 11 (HPV11). C/EBPbeta is in nuclei of cultured foreskin keratinocytes and binds its consensus sequence in HPV11 DNA. We have used the novel approach of depleting the availability of C/EBPs in vivo using nuclease-resistant oligomers containing C/EBP DNA binding sites. In cultured foreskin keratinocytes containing replicating HPV11 DNA, levels of both HPV11 transcripts and HPV DNA increase after treatment with oligomers; containing the C/EBPbeta DNA binding motif. These results indicate that C/EBPbeta is a repressor for HPV11 in keratinocytes.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.70.7.4839-4844.1996

Reference57 articles.

1. Regulation of expression of the interleukin 6 gene: structure and function of the transcription factor NF-IL6;Akira S.;Ciba Found. Symp.,1992

2. IL-6 and NF-IL6 in acute-phase response and viral infection;Akira S.;Immunol. Rev.,1992

3. Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response;Alam T.;J. Biol. Chem.,1992

4. Heterogeneity in the replicating population of cultured human epidermal keratinocytes;Albers K. M.;Differentiation,1986

5. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death;Amati B.;Curr. Opin. Genet. Dev.,1994

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