Antiviral Peptides Targeting the Helicase Activity of Enterovirus Nonstructural Protein 2C

Author:

Fang Yuan12,Wang Chang23,Wang Chong2,Yang Ruyi23,Bai Peng1,Zhang Xue-Yi12,Kong Jing23,Yin Lei1,Qiu Yang23,Zhou Xi123ORCID

Affiliation:

1. State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

2. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

3. The University of Chinese Academy of Sciences, Beijing, China

Abstract

Enteroviruses are a large group of positive-sense single-stranded RNA viruses and include numerous human pathogens, such as enterovirus A71 (EV-A71), coxsackieviruses, and echoviruses. However, no approved EV antiviral drugs are available.

Funder

CAS Youth Innovation Promotion Association

MOE | Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Strategic Priority Research Program of CAS

National Science and Technology Major Project

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference38 articles.

1. Pallansch MA. 2007. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses, p 840–893. In Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (ed), Fields virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.

2. Antiviral Activity of Coxsackievirus B3 3C Protease Inhibitor in Experimental Murine Myocarditis

3. Coxsackie B Viruses and Human Heart Disease

4. Coxsackievirus B3 murine myocarditis: Wide pathologic spectrum in genetically defined inbred strains

5. Myocarditis

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