The luxS Gene Is Not Required for Borrelia burgdorferi Tick Colonization, Transmission to a Mammalian Host, or Induction of Disease-Reference-Cited by-同舟云学术

The luxS Gene Is Not Required for Borrelia burgdorferi Tick Colonization, Transmission to a Mammalian Host, or Induction of Disease

Published:2004-08 Issue:8 Volume:72 Page:4864-4867
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Blevins Jon S.¹,Revel Andrew T.¹,Caimano Melissa J.²,Yang Xiaofeng F.¹,Richardson James A.³,Hagman Kayla E.¹,Norgard Michael V.¹

Affiliation:

1. Departments of Microbiology

2. Department of Pathology and Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030

3. Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390

Abstract

ABSTRACT luxS mutants of Borrelia burgdorferi strain 297 naturally colonized their arthropod ( Ixodes scapularis ) vector, were maintained in ticks throughout the molting process (larvae to nymphs), were tick transmitted to uninfected mice, and elicited histopathology in mice indistinguishable from that induced by wild-type B. burgdorferi .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.8.4864-4867.2004

Reference30 articles.

1. Borrelia burgdorferi Gene Expression In Vivo and Spirochete Pathogenicity

2. Armstrong, A. L., S. W. Barthold, D. H. Persing, and D. S. Beck. 1992. Carditis in Lyme disease susceptible and resistant strains of laboratory mice infected with Borrelia burgdorferi. Am. J. Trop. Med. Hyg.47:249-258.

3. Barthold, S. W., D. S. Beck, G. M. Hansen, A. A. Terwilliger, and K. D. Moody. 1990. Lyme borreliosis in selected strains and ages of laboratory mice. J. Infect. Dis.162:133-138.

4. Barthold, S. W., M. S. de Souza, J. L. Janotka, A. L. Smith, and D. H. Persing. 1993. Chronic Lyme borreliosis in the laboratory mouse. Am. J. Pathol.143:959-971.

5. Barthold, S. W., D. H. Persing, A. L. Armstrong, and R. A. Peeples. 1991. Kinetics of Borrelia burgdorferi dissemination and evolution of disease after intradermal inoculation of mice. Am. J. Pathol.139:263-273.

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