Genetic Susceptibility of Mice to Candida albicans Vaginitis Correlates with Host Estrogen Sensitivity-Reference-Cited by-同舟云学术

Genetic Susceptibility of Mice to Candida albicans Vaginitis Correlates with Host Estrogen Sensitivity

Published:2004-08 Issue:8 Volume:72 Page:4878-4880
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Clemons Karl V.¹²³,Spearow Jimmy L.⁴,Parmar Rachana¹,Espiritu Marife¹,Stevens David A.¹²³

Affiliation:

1. California Institute for Medical Research

2. Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, California 95128

3. Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California 94305

4. Section on Neurobiology, Physiology and Behavior, University of California, Davis, California 95616

Abstract

ABSTRACT We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 ≥ CD10 ≥ CD10 × CD3F1 > CD10 × B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 × B6F1 animals and dominant in CD10 × CD3F1 animals.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.8.4878-4880.2004

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