Antibody Escape Kinetics of Equine Infectious Anemia Virus Infection of Horses-Reference-Cited by-同舟云学术

Antibody Escape Kinetics of Equine Infectious Anemia Virus Infection of Horses

Published:2015-07 Issue:13 Volume:89 Page:6945-6951
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Schwartz Elissa J.¹,Nanda Seema²,Mealey Robert H.³

Affiliation:

1. School of Biological Sciences and Department of Mathematics, Washington State University, Pullman, Washington, USA

2. Centre for Applicable Mathematics, Tata Institute of Fundamental Research, Bangalore, India

3. Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA

Abstract

ABSTRACT Lentivirus escape from neutralizing antibodies (NAbs) is not well understood. In this work, we quantified antibody escape of a lentivirus, using antibody escape data from horses infected with equine infectious anemia virus. We calculated antibody blocking rates of wild-type virus, fitness costs of mutant virus, and growth rates of both viruses. These quantitative kinetic estimates of antibody escape are important for understanding lentiviral control by antibody neutralization and in developing NAb-eliciting vaccine strategies.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00137-15

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