Abstract
Cefoxitin was administered in a dose of 2 g intravenously to 17 patients scheduled for cholecystectomy. The concentrations of this agent in serum and gallbladder bile were measured simultaneously upon opening of the abdominal cavity. Concentrations of cefoxitin in excess of 10 microgram/ml were present in the gallbladder bile of 12 of the 13 patients from samples obtained between 35 and 165 min after cefoxitin infusion. Cystic or common duct obstruction did not preclude entry of the drug into gallbladder bile.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference21 articles.
1. Cefoxitin and cephalothin: antimicrobial activity, human pharmacokinetics, and toxicology;Brumfitt W.;Antimicrob. Agents Chemother.,1974
2. Preoperative antibiotics in biliary surgery;Chetln S. H.;Arch. Surg.,1973
3. Serum and tissue levels of cefoxitin in perioperative prophylaxis;Herltz V.;J Antimicrob. Chemother.,1980
4. Biliary concentrations of cefamandole and its use in biliary tract surgery;Lev I;Scand. J. Infect. Dis. Suppl.,1980
5. Biliary levels of cefoxitin;Lopn R. N.;J. Antimicrob. Chemother.,1979
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献