EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling-Reference-Cited by-同舟云学术

EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling

Published:2020-03-16 Issue:7 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Tom Eric C.¹²,Mushtaq Insha¹³,Mohapatra Bhopal C.¹⁴,Luan Haitao¹,Bhat Aaqib M.¹⁴,Zutshi Neha¹³,Chakraborty Sukanya¹⁴,Islam Namista¹⁴,Arya Priyanka¹⁴,Bielecki Timothy A.¹,Iseka Fany M.¹⁴,Bhattacharyya Sohinee¹³,Cypher Luke R.¹,Goetz Benjamin T.¹,Negi Simarjeet K.⁴,Storck Matthew D.¹,Rana Sandeep¹,Barnekow Angelika⁵,Singh Pankaj K.¹²³⁴⁶,Ying Guoguang⁷,Guda Chittibabu⁴⁶,Natarajan Amarnath¹⁶,Band Vimla¹⁴⁶,Band Hamid¹²³⁴⁶^ORCID

Affiliation:

1. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA

2. Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA

3. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA

4. Department of Genetics, Cell Biology and Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA

5. Department of Experimental Tumorbiology, Westfälische Wilhelms University Muenster, Muenster, Germany

6. Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA

7. Laboratory of Cancer Cell Biology, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

Abstract

Epidermal growth factor receptor (EGFR) is a prototype receptor tyrosine kinase and an oncoprotein in many solid tumors. Cell surface display of EGFR is essential for cellular responses to its ligands. While postactivation endocytic trafficking of EGFR has been well elucidated, little is known about mechanisms of basal/preactivation surface display of EGFR. Here, we identify a novel role of the endocytic regulator EHD1 and a potential EHD1 partner, RUSC2, in cell surface display of EGFR. EHD1 and RUSC2 colocalize with EGFR in vesicular/tubular structures and at the Golgi compartment.

Funder

HHS | National Institutes of Health

U.S. Department of Defense

Nebraska Department of Health and Human Services

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00434-19

Reference89 articles.

1. Targeting RTK signaling pathways in cancer;Regad T;Cancers (Basel),2015