Reduction of bacterial titers by low-dose aspirin in experimental aortic valve endocarditis

Author:

Nicolau D P1,Freeman C D1,Nightingale C H1,Quintiliani R1,Coe C J1,Maderazo E G1,Cooper B W1

Affiliation:

1. Department of Pharmacy, Hartford Hospital, Connecticut 06115.

Abstract

Using a rabbit model of Staphylococcus aureus endocarditis, we studied the effects of aspirin on the natural progression of this infection. Compared with untreated animals, the aspirin-treated animals showed a 30% (P = 0.11) reduction in the weight of the vegetations and an 84% (P = 0.03) reduction in the bacterial titer of the vegetations.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference21 articles.

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2. Platelet interaction with bacteria. I. Reaction phases and effects of inhibitors;Clawson C. C.;Am. J. Pathol.,1971

3. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation;Durack D. T.;Br. J. Exp. Pathol.,1972

4. Experimental bacterial endocarditis. III. Production and progress of the disease in rabbits;Durack D. T.;Br. J. Exp. Pathol.,1973

5. Effect of oral aspirin dose on platelet aggregation and vascular prostacyclin synthesis in humans and rabbits;Ellis E. F.;J. Cardiovasc. Pharmacol.,1980

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