Viral Evolution during Structured Treatment Interruptions in Chronically Human Immunodeficiency Virus-Infected Individuals-Reference-Cited by-同舟云学术

Viral Evolution during Structured Treatment Interruptions in Chronically Human Immunodeficiency Virus-Infected Individuals

Published:2002-12 Issue:23 Volume:76 Page:12344-12348
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Martinez-Picado Javier¹,Frost Simon D. W.²,Izquierdo Nuria¹,Morales-Lopetegi K.¹,Marfil Silvia¹,Puig Teresa¹,Cabrera Cecilia¹,Clotet Bonaventura¹,Ruiz Lidia¹

Affiliation:

1. IrsiCaixa Foundation, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain

2. University of California at San Diego Antiviral Research Center, San Diego, California

Abstract

ABSTRACT We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.23.12344-12348.2002

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