Use of High-Performance Liquid Chromatography To Study the Pharmacokinetics of Colistin Sulfate in Rats following Intravenous Administration-Reference-Cited by-同舟云学术

Use of High-Performance Liquid Chromatography To Study the Pharmacokinetics of Colistin Sulfate in Rats following Intravenous Administration

Published:2003-05 Issue:5 Volume:47 Page:1766-1770
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Li Jian¹,Milne Robert W.¹,Nation Roger L.¹,Turnidge John D.²,Smeaton Timothy C.³,Coulthard Kingsley⁴

Affiliation:

1. Centre for Pharmaceutical Research

2. Department of Microbiology and Infectious Diseases

3. School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide

4. Department of Pharmacy, Women's and Children's Hospital, North Adelaide, Australia

Abstract

ABSTRACT The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.5.1766-1770.2003

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