Mechanisms of Acquired In Vivo and In Vitro Resistance to Voriconazole by Candida krusei following Exposure to Suboptimal Drug Concentration-Reference-Cited by-同舟云学术

Mechanisms of Acquired In Vivo and In Vitro Resistance to Voriconazole by Candida krusei following Exposure to Suboptimal Drug Concentration

Published:2020-03-24 Issue:4 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ricardo Elisabete¹²,Grenouillet Fréderic³⁴,Miranda Isabel M.¹⁵,Silva Raquel M.⁶,Eglin Guilluame³,Devillard Nadège⁷,Rodrigues Acácio Gonçalves¹²⁸,Pina-Vaz Cidália¹²

Affiliation:

1. Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal

2. CINTESIS – Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal

3. Medical Biology Department, University Hospital, Besançon, France

4. UMR UBFC-CNRS 6249 ChronoEnvironnement, University of Bourgogne-Franche Comte, Besançon, France

5. Cardiovascular R&D Unit, Faculty of Medicine of the University of Porto, Porto, Portugal

6. Department of Medical Sciences and iBiMED, University of Aveiro, Aveiro, Portugal

7. Nephrology Department, University Hospital, Besançon, France

8. Burn Unit, Department of Plastic and Reconstructive Surgery, Centro Hospitalar S. João, EPE, Porto, Portugal

Abstract

Five Candida krusei isolates (susceptible and resistant) recovered from the urine of a kidney transplant patient treated with voriconazole (VRC) 200 mg twice daily for 20 days were studied. Eight unrelated clinical isolates of C. krusei were exposed in vitro to VRC 0.001 μg/ml for 30 days. Development of VRC transient resistance occurred in vivo , and induction of permanent resistance occurred in vitro .

Funder

FEDER, FCT

Ministry of Education and Science | Fundação para a Ciência e a Tecnologia

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01651-19

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2. Diagnosis and Management of Fungal Urinary Tract Infection