Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection-Reference-Cited by-同舟云学术

Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sharma Dipti¹,Paul Raees A.¹,Rudramurthy Shivaprakash M.¹^ORCID,Kashyap Nisha¹,Bhattacharya Sanjay²,Soman Rajeev³,Shankarnarayan Shamanth A.¹,Chavan Dipali³,Singh Shreya¹,Das Parijit²,Kaur Harsimran¹,Ghosh Anup K.¹^ORCID,Prasad Rajendra⁴,Sanyal Kaustuv⁵^ORCID,Chakrabarti Arunaloke¹^ORCID

Affiliation:

1. Department of Medical Microbiology, PGIMER, Chandigarh, India

2. Tata Medical Centre, Kolkata, India

3. Jupiter Hospital, Pune, India

4. Amity Institute of Biotechnology & Integrative Sciences and Health, Amity University Haryana, Gurgaon, India

5. Jawaharlal Nehru Center for Advanced Scientific Research, Bengaluru, India

Abstract

Echinocandins are frontline antifungal agents in the management of invasive infections due to multidrug resistant Candida auris . The study aimed to evaluate echinocandin resistance in C. auris isolates of multicentric origin, identify the resistance mechanism, and analyze the pharmacodynamic response to caspofungin in a neutropenic mouse model of infection.

Funder

University Grants Commission

Indian Council of Medical Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01652-21

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