Prevalence and Conditions of Selection of E44D/A and V118I Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in Clinical Practice-Reference-Cited by-同舟云学术

Prevalence and Conditions of Selection of E44D/A and V118I Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in Clinical Practice

Published:2001-03 Issue:3 Volume:45 Page:946-948
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Delaugerre Constance¹,Mouroux Mireille¹,Yvon-Groussin Anne¹,Simon Anne²,Angleraud Francis¹,Huraux Jean-Marie¹,Agut Henri¹,Katlama Christine³,Calvez Vincent¹

Affiliation:

1. Departments of Virology,1

2. Internal Medicine,2 and

3. Infectious Diseases,3 Pitié-Salpêtrière Hospital, Paris, France

Abstract

ABSTRACT Recently, it has been shown that a new mutational pattern (the E44D/A and/or V118I mutation) confers moderate phenotypic lamivudine resistance in the absence of the M184V mutation. The E44D/A and/or the V118I mutation does not exist in drug-naive patients, and the prevalence increases with the number of treatment regimens and lamivudine experience. The mutations can preexist in nucleoside-experienced but lamivudine-naive patients. They are always associated with zidovudine resistance-associated mutations, even in the absence of M184V. These mutations are more stable than the M184V substitution during antiretroviral treatment interruptions.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.3.946-948.2001

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