A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity upon Viral Infection and Advanced Age-Reference-Cited by-同舟云学术

A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity upon Viral Infection and Advanced Age

Published:2021-07-15 Issue:8 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Joma Basma H.¹²,Siwapornchai Nalat¹,Vanguri Vijay K.³,Shrestha Anishma¹,Roggensack Sara E.¹⁴,Davidson Bruce A.⁵,Tai Albert K.⁶,Hakansson Anders P.⁷^ORCID,Meydani Simin N.⁸,Leong John M.¹⁹,Bou Ghanem Elsa N.¹⁰^ORCID

Affiliation:

1. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA

2. Graduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, Massachusetts, USA

3. UMass Memorial Health Care, University of Massachusetts Medical School, Worcester, Massachusetts, USA

4. Graduate Program in Molecular Microbiology, Tufts Graduate School of Biomedical Sciences, Boston, Massachusetts, USA

5. Department of Anesthesiology, University at Buffalo School of Medicine, Buffalo, New York, USA

6. Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, USA

7. Department of Translational Medicine, Lund University, Malmö, Sweden

8. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA

9. Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance at Tufts (Levy CIMAR), Boston, Massachusetts, USA

10. Department of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, USA

Abstract

Streptococcus pneumoniae (pneumococcus) resides asymptomatically in the nasopharynx (NP) but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation with influenza A virus (IAV) but did not fully recapitulate the severe disease associated with human coinfection.

Funder

King Abdullah Scholarship Program

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute on Aging

NIH

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00471-20

Reference83 articles.