Cyclopropane Fatty Acids Are Important for Salmonella enterica Serovar Typhimurium Virulence

Author:

Karlinsey Joyce E.1ORCID,Fung Angela M.2,Johnston Norah3,Goldfine Howard3,Libby Stephen J.2,Fang Ferric C.21ORCID

Affiliation:

1. Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA

2. Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA

3. Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

Abstract

A variety of eubacteria, plants, and protozoa can modify membrane lipids by cyclopropanation, which is reported to modulate membrane permeability and fluidity. The ability to cyclopropanate membrane lipids has been associated with resistance to oxidative stress in Mycobacterium tuberculosis , organic solvent stress in Escherichia coli , and acid stress in E. coli and Salmonella .

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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