Use of an Interspecies Chimeric Receptor for Inducible Gene Expression Reveals that Metabolic Flux through the Peptidoglycan Biosynthesis Pathway is an Important Driver of Cephalosporin Resistance in Enterococcus faecalis-Reference-Cited by-同舟云学术

Use of an Interspecies Chimeric Receptor for Inducible Gene Expression Reveals that Metabolic Flux through the Peptidoglycan Biosynthesis Pathway is an Important Driver of Cephalosporin Resistance in Enterococcus faecalis

Published:2022-04-19 Issue:4 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Mascari Carly A.¹,Djorić Dušanka¹,Little Jaime L.¹,Kristich Christopher J.¹

Affiliation:

1. Department of Microbiology and Immunology, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

Abstract

Enterococci are dangerous opportunistic pathogens with the potential to cause life-threatening infections due in part to their intrinsic resistance to cephalosporin antibiotics. Elucidating the molecular mechanisms that provide this resistance is critical for the development of strategies to both prevent and treat enterococcal infections.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00602-21

Reference31 articles.

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2. Intrinsic and acquired resistance mechanisms in enterococcus

3. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications

4. Infective endocarditis

5. Antecedent Treatment with Different Antibiotic Agents as a Risk Factor for Vancomycin-ResistantEnterococcus

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