High Rate of Fatal Cases of Pediatric Septicemia Caused by Gram-Negative Bacteria with Extended-Spectrum Beta-Lactamases in Dar es Salaam, Tanzania-Reference-Cited by-同舟云学术

High Rate of Fatal Cases of Pediatric Septicemia Caused by Gram-Negative Bacteria with Extended-Spectrum Beta-Lactamases in Dar es Salaam, Tanzania

Published:2005-02 Issue:2 Volume:43 Page:745-749
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Blomberg Bjørn¹²³,Jureen Roland²,Manji Karim P.⁴,Tamim Bushir S.⁴,Mwakagile Davis S. M.⁵,Urassa Willy K.⁵,Fataki Maulidi⁴,Msangi Viola⁵,Tellevik Marit G.²,Maselle Samwel Y.¹⁵,Langeland Nina²³

Affiliation:

1. Centrefor International Health

2. Institute ofMedicine, University of Bergen

3. Haukeland UniversityHospital, Bergen, Norway

4. Department of Paediatrics andChild Health

5. Department of Microbiologyand Immunology, Muhimbili University College ofHealth Sciences, Dar es Salaam, Tanzania

Abstract

ABSTRACT Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.43.2.745-749.2005

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