The Pup-Proteasome System Protects Mycobacteria from Antimicrobial Antifolates-Reference-Cited by-同舟云学术

The Pup-Proteasome System Protects Mycobacteria from Antimicrobial Antifolates

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Guzzo Marissa B.¹²³,Li Qing¹³,Nguyen Hoang V.²,Boom W. Henry¹³,Nguyen Liem¹²³^ORCID

Affiliation:

1. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

2. Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

3. University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

Abstract

Protein turnover via the Pup-proteasome system (PPS) is essential for nitric oxide resistance and virulence of Mycobacterium tuberculosis , the causative agent of tuberculosis. Our study revealed components of PPS as novel determinants of intrinsic antifolate resistance in both M. tuberculosis and nonpathogenic M. smegmatis .

Funder

The Roe Green Center for Travel Medicine

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01967-20

Reference66 articles.

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2. World Health Organization. 2016. Global tuberculosis report 2016. World Health Organization, Geneva, Switzerland.