Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi-Reference-Cited by-同舟云学术

Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Negreiros Raquel S.¹,Lander Noelia²³,Chiurillo Miguel A.²³,Vercesi Anibal E.¹,Docampo Roberto²^ORCID

Affiliation:

1. Department of Clinical Pathology, State University of Campinas, Campinas, São Paulo, Brazil

2. Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, USA

3. Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA

Abstract

Trypanosoma cruzi is the causative agent of Chagas disease. Pyruvate is the end product of glycolysis, and its transport into the mitochondrion is mediated by the mitochondrial pyruvate carrier (MPC) subunits.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00540-21

Reference59 articles.

1. The long and winding road to the mitochondrial pyruvate carrier

2. The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier