Deficient Phagocytosis in Circulating Monocytes from Patients with COVID-19-Associated Mucormycosis

Author:

Sinha Bishnu Prasad12,Mehta Priyanka32,Hoque Md Asmaul12,Bandopadhyay Purbita12,Nandi Ayandip4,Saha Ipsita4,Nandi Mitra Anita5,Mondal Asish6,Bhattacharjee Boudhayan7,Chamilos Georgios89ORCID,Pandey Rajesh32ORCID,Basu Kaushik6,Ganguly Dipyaman12ORCID

Affiliation:

1. IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata, India

2. Academy of Scientific and Innovative Research, Ghaziabad, India

3. INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology, Delhi, India

4. Department of Pathology, Medical College, Kolkata, India

5. Department of Microbiology, Medical College, Kolkata, India

6. Department of General Medicine, Medical College, Kolkata, India

7. Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India

8. Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology - Hellas (IMBB FoRTH), Heraklion, Greece

9. Department of Clinical Microbiology and Microbial Pathogenesis, School of Medicine, University of Crete, Heraklion, Greece

Abstract

A number of cases of mucormycosis, often fatal, were reported among severe COVID-19 patients from India as well as from some other parts of the world. However, specific immunocellular mechanisms that underlie susceptibility to this fungal infection in COVID-19 remain largely unexplored.

Funder

CSIR | CSIR – Indian Institute of Chemical Biology

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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