Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant-Reference-Cited by-同舟云学术

Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Leslie Jhansi L.¹^ORCID,Jenior Matthew L.¹^ORCID,Vendrov Kimberly C.²^ORCID,Standke Alexandra K.²^ORCID,Barron Madeline R.¹^ORCID,O’Brien Tricia J.²,Unverdorben Lavinia¹,Thaprawat Pariyamon¹^ORCID,Bergin Ingrid L.³,Schloss Patrick D.¹^ORCID,Young Vincent B.¹²^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

2. Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

3. The Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA

Abstract

Antibiotic-associated colitis is often caused by infection with the bacterium Clostridioides difficile . In this study, we found that reduction of the amino acid glycine by precolonization with a less virulent strain of C. difficile is sufficient to decrease germination of a second strain.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00522-21

Reference54 articles.

1. Burden ofClostridium difficileInfection in the United States