Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex-Reference-Cited by-同舟云学术

Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex

Published:2023-06-27 Issue:3 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Mann Beth¹,Crawford Jeremy Chase²,Reddy Kavya¹,Lott Josi¹,Youn Yong Ha³,Gao Geli¹,Guy Cliff²,Chou Ching-Heng²,Darnell Daniel⁴,Trivedi Sanchit⁴,Bomme Perrine¹,Loughran Allister J.¹,Thomas Paul G.²,Han Young-Goo³^ORCID,Tuomanen Elaine I.¹^ORCID

Affiliation:

1. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

2. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

3. Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

4. Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

Abstract

Fetal brain development in early gestation can be impacted by transplacental infection, altered metabolites from the maternal microbiome, or maternal immune activation. It is less well understood how maternal microbial subcomponents that cross the placenta, such as bacterial cell wall (BCW), directly interact with fetal neural progenitors and neurons and affect development.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | NIH Blueprint for Neuroscience Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00510-23

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