In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry-Reference-Cited by-同舟云学术

In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Vallbracht Melina¹^ORCID,Lötzsch Henriette¹,Klupp Barbara G.¹,Fuchs Walter¹,Vollmer Benjamin²,Grünewald Kay²,Backovic Marija³,Rey Felix A.³,Mettenleiter Thomas C.¹

Affiliation:

1. Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

2. Centre for Structural Systems Biology, Heinrich-Pette-Institut, Leibniz-Institut für Experimentelle Virologie, Hamburg, Germany

3. Institut Pasteur, Structural Virology Unit, Department of Virology, CNRS UMR3569, Paris, France

Abstract

The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00557-21

Reference64 articles.

1. Viral membrane fusion

2. Class III Viral Membrane Fusion Proteins

3. Common characteristics and unique features: A comparison of the fusion machinery of the alphaherpesviruses Pseudorabies virus and Herpes simplex virus