Isolation of a Potently Neutralizing and Protective Human Monoclonal Antibody Targeting Yellow Fever Virus

Author:

Doyle Michael P.1,Genualdi Joseph R.1,Bailey Adam L.2,Kose Nurgun3,Gainza Christopher3,Rodriguez Jessica3,Reeder Kristen M.3,Nelson Christopher A.2,Jethva Prashant N.4,Sutton Rachel E.3,Bombardi Robin G.3,Gross Michael L.4,Julander Justin G.5ORCID,Fremont Daved H.267ORCID,Diamond Michael S.278,Crowe James E.139ORCID

Affiliation:

1. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

3. The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA

4. Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri, USA

5. Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA

6. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA

7. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

8. Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

9. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Yellow fever virus (YFV) is a mosquito-borne virus that occasionally causes outbreaks of severe infection and disease in South America and sub-Saharan Africa. There are very effective live-attenuated (weakened) yellow fever virus vaccines, but recent problems with their production and distribution have left many people in affected areas vulnerable.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Merck KGaA

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3