Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile-Reference-Cited by-同舟云学术

Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile

Published:2021-05-18 Issue: Volume: Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Garcia-Garcia Transito¹,Poncet Sandrine²,Cuenot Elodie¹,Douché Thibaut³,Giai Gianetto Quentin³⁴,Peltier Johann¹⁵^ORCID,Courtin Pascal²,Chapot-Chartier Marie-Pierre²^ORCID,Matondo Mariette³,Dupuy Bruno¹,Candela Thomas²,Martin-Verstraete Isabelle¹⁶^ORCID

Affiliation:

1. Laboratoire Pathogénese des Bactéries Anaérobies, Institut Pasteur, UMR CNRS 2001, Université de Paris, Paris, France

2. Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France

3. Plateforme Protéomique, Unité de Technologie et Service Spectrométrie de Masse pour la Biologie, CNRS USR 2000, Institut Pasteur, Paris, France

4. Hub de Bioinformatique et Statistique, Departement de Biologie Computationelle, USR3756, Institut Pasteur, Paris, France

5. Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cells (I2BC), Gif-sur-Yvette, France

6. Institut Universitaire de France, Paris, France

Abstract

Bacterial cells are encased in a PG exoskeleton that helps to maintain cell shape and confers physical protection. To allow bacterial growth and cell separation, PG needs to be continuously remodeled by hydrolytic enzymes that cleave PG at critical sites.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00519-21

Reference81 articles.

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4. Autolysins of Bacillus subtilis: multiple enzymes with multiple functions

5. Bacterial peptidoglycan (murein) hydrolases

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