A Dual-Specificity Inhibitor Targets Polyphosphate Kinase 1 and 2 Enzymes To Attenuate Virulence of Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

A Dual-Specificity Inhibitor Targets Polyphosphate Kinase 1 and 2 Enzymes To Attenuate Virulence of Pseudomonas aeruginosa

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Neville Nolan¹,Roberge Nathan¹,Ji Xiang²³,Stephen Preyesh¹,Lu Jiasheng Louis²⁴,Jia Zongchao¹^ORCID

Affiliation:

1. Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada

2. Risen (Shanghai) Pharma Tech Co., Ltd., Shanghai, China

3. Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai, China

4. Guangdong Key Laboratory of Nanomedicine, Chinese Academy of Sciences, Shenzhen, China

Abstract

Many priority bacterial pathogens such as P. aeruginosa encode both PPK1 and PPK2 enzymes to maintain polyphosphate homeostasis. While PPK1 and PPK2 have distinct structures and catalytic mechanisms, they are both capable of synthesizing and consuming polyphosphate; thus, PPK2 enzymes can compensate for the loss of PPK1 and vice versa.

Funder

Cystic Fibrosis Canada

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00592-21

Reference56 articles.

1. Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa

2. Inorganic Polyphosphate Is Required for Motility of Bacterial Pathogens