A Recombinant Attenuated Yersinia pseudotuberculosis Vaccine Delivering a Y. pestis YopE Nt138 -LcrV Fusion Elicits Broad Protection against Plague and Yersiniosis in Mice-Reference-Cited by-同舟云学术

A Recombinant Attenuated Yersinia pseudotuberculosis Vaccine Delivering a Y. pestis YopE Nt138 -LcrV Fusion Elicits Broad Protection against Plague and Yersiniosis in Mice

Published:2019-10 Issue:10 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Singh Amit K.¹,Curtiss Roy²,Sun Wei¹

Affiliation:

1. Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA

2. Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA

Abstract

In this study, a novel recombinant attenuated Yersinia pseudotuberculosis PB1+ strain (χ10069) engineered with Δ yopK Δ yopJ Δ asd triple mutations was used to deliver a Y. pestis fusion protein, YopE amino acid 1 to 138-LcrV (YopE Nt138 -LcrV), to Swiss Webster mice as a protective antigen against infections by yersiniae.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00296-19

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2. Pathogenesis ofY. enterocoliticaandY. pseudotuberculosisin Human Yersiniosis

3. Defective Innate Cell Response and Lymph Node Infiltration Specify Yersinia pestis Infection