Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable Haemophilus influenzae Increases Complement-Mediated Killing-Reference-Cited by-同舟云学术

Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable Haemophilus influenzae Increases Complement-Mediated Killing

Published:2019-08 Issue:8 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Langereis Jeroen D.¹²^ORCID,van der Pasch Eva S.¹²,de Jonge Marien I.¹²

Affiliation:

1. Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

2. Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands

Abstract

Nontypeable Haemophilus influenzae (NTHi) colonizes the human upper respiratory tract without causing disease symptoms, but it is also a major cause of upper and lower respiratory tract infections in children and elderly, respectively. NTHi synthesizes various molecules to decorate its lipooligosaccharide (LOS), which modulates the level of virulence.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00299-19

Reference48 articles.

1. Variability and Diversity of Nasopharyngeal Microbiota in Children: A Metagenomic Analysis

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3. Nontypeable Haemophilus influenzae as a Pathogen in Children

4. Epidemiology of community-acquired pneumonia in older adults: A population-based study

5. Persistent Colonization byHaemophilus influenzaein Chronic Obstructive Pulmonary Disease

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