Affiliation:
1. Sterling-Winthrop Research Institute, Rensselaer, New York 12144
Abstract
Penicillium adametzi
and seven other species convert nalidixic acid, 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid, to 1,4-dihydro-1-ethyl-7-hydroxymethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid. Forty-seven other species from six orders of fungi seem to achieve the same conversion as judged by chromatographic and spectral evidence. Under special conditions,
P. adametzi
also produces a second metabolite which was identified as the corresponding 7-carboxylic acid. The metabolic attack on the ring substituent is identical with the pathway previously established with humans. No evidence was obtained for metabolic attack on the naphthyridine nucleus itself.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference16 articles.
1. Biodegradation. Problems of molecular recalcitrance and microbial fallibility;Alexander M.;Advan. Appl. Microbiol.,1965
2. Buchbinder M. J. C. Webb L. V. Anderson and W. R. McCabe. 1963. Laboratory studies and clinical pharma cology of nalidixic acid (Win 18 320). Antimicrobial Agents and Chemotherapy-1962 p. 308-317.
3. Deitz W. H. J. H. Bailey and E. J. Froelich. 1964. In vitro antibacterial properties of nalidixic acid a new drug active against gram-negative organisms. Antimicrobial Agents and Chemotherapy-1963 p. 583-587.
4. Mechanism of action of nalidixic acid on Escherichia coli. II. Inhibition of deoxyribonucleic acid synthesis;Goss W. A.;J. Bacteriol.,1965
5. Hydroxylation of progesterone and 11-desoxy-17-corticosterone by Aspergillus and;Dulaney E. L.;Penicillium. Appl. Microbiol.,1955
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献