Duck Enteritis Virus Inhibits the cGAS-STING DNA-Sensing Pathway To Evade the Innate Immune Response

Author:

Gao Li1,Liu Rui1,Yang Fuchun1,Li Xiaohan1,Liu Changjun1,Qi Xiaole1,Cui Hongyu1,Zhang Yanping1,Wang Suyan1,Wang Xiaomei12ORCID,Gao Yulong1ORCID,Li Kai1ORCID

Affiliation:

1. Avian Immunosuppressive Diseases Division, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou, China

Abstract

Duck enteritis virus (DEV) is a duck alphaherpesvirus that causes an acute and contagious disease with high mortality, resulting in substantial economic losses in the commercial waterfowl industry. The evasion of DNA-sensing pathway-mediated antiviral innate immunity is essential for the persistent infection and replication of many DNA viruses.

Funder

Natural Science Foundation of Heilongjiang Province

National Natural Science Foundation of China

MOA | CAFS | Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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