In Vitro Effectiveness of Povidone-Iodine on Acanthamoeba Isolates from Human Cornea-Reference-Cited by-同舟云学术

In Vitro Effectiveness of Povidone-Iodine on Acanthamoeba Isolates from Human Cornea

Published:1998-09 Issue:9 Volume:42 Page:2232-2234
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gatti Simonetta¹,Cevini Claudia¹,Bruno Antonella²,Penso Gabriella³,Rama Paolo⁴,Scaglia Massimo²

Affiliation:

1. Laboratory of Parasitology, Virology Unit, IRCCS,1 and

2. Infectious Diseases Research Laboratories (Laboratory of Clinical Parasitology), University-IRCCS,2 San Matteo, Pavia, Italy, and

3. Laboratory of Biochemistry and Microbiology3 and

4. Division of Ophthalmology,4 Venice Hospital, Venice, Italy

Abstract

ABSTRACT Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious topical and systemic drugs. We evaluated the in vitro effectiveness of povidone-iodine (PVP-I [Betadine]), an agent with broad antibacterial and antiviral activity, compared to that of chlorhexidine (CXD), a cationic antiseptic, on Acanthamoeba isolates from patients with amebic keratitis. The results showed that PVP-I solution from 0.5 to 2.5% has a better antiamebic activity both on trophic and cystic stages of Acanthamoeba spp. than does CXD.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.9.2232

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