Performance of Saliva, Oropharyngeal Swabs, and Nasal Swabs for SARS-CoV-2 Molecular Detection: a Systematic Review and Meta-analysis

Author:

Lee Rose A.12,Herigon Joshua C.1,Benedetti Andrea3,Pollock Nira R.24ORCID,Denkinger Claudia M.5ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Pediatrics, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

3. Department of Medicine and of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Quebec, Canada

4. Department of Laboratory Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA

5. Division of Clinical Tropical Medicine, Center of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany

Abstract

Nasopharyngeal (NP) swabs are considered the highest-yield sample for diagnostic testing for respiratory viruses, including SARS-CoV-2. The need to increase capacity for SARS-CoV-2 testing in a variety of settings, combined with shortages of sample collection supplies, have motivated a search for alternative sample types with high sensitivity.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference75 articles.

1. U.S. Food and Drug Administration Center for Devices and Radiological Health. 2020. FAQs on testing for SARS-CoV-2. https://www.fda.gov/medical-devices/coronavirus-covid-19-and-medical-devices/faqs-testing-sars-cov-2. Accessed 12 October 2020.

2. Centers for Disease Control and Prevention. 2020. Information for laboratories about coronavirus (COVID-19). https://www.cdc.gov/coronavirus/2019-ncov/lab/guidelines-clinical-specimens.html. Accessed 4 October 2020.

3. Posterior Oropharyngeal Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

4. A pneumonia outbreak associated with a new coronavirus of probable bat origin

5. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

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