Pep5, a Fragment of Cyclin D2, Shows Antiparasitic Effects in Different Stages of the Trypanosoma cruzi Life Cycle and Blocks Parasite Infectivity-Reference-Cited by-同舟云学术

Pep5, a Fragment of Cyclin D2, Shows Antiparasitic Effects in Different Stages of the Trypanosoma cruzi Life Cycle and Blocks Parasite Infectivity

Published:2019-05 Issue:5 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

de Araujo Christiane Bezerra¹²,de Lima Loyze Paola¹²,Calderano Simone Guedes³,Silva Damasceno Flávia⁴,Silber Ariel M.⁴,Elias Maria Carolina¹²

Affiliation:

1. Laboratório Especial de Ciclo Celular, Instituto Butantan, São Paulo, Brazil

2. Center of Toxins, Immune Response and Cell Signaling (CeTICS), Instituto Butantan, São Paulo, Brazil

3. Laboratório de Parasitologia, Instituto Butantan, São Paulo, Brazil

4. Laboratory of Biochemistry of Tryps (LaBTryps), Departamento de Parasitologia, Instituto de Ciências Biomédicas, São Paulo, Brazil

Abstract

Pep5 (WELVVLGKL) is a fragment of cyclin D2 that exhibits a 2-fold increase in the S phase of the HeLa cell cycle. When covalently bound to a cell-penetrating peptide (Pep5-cpp), the nonapeptide induces cell death in several tumor cells, including breast cancer and melanoma cells.

Funder

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01806-18

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