Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection-Reference-Cited by-同舟云学术

Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection

Published:2022-01-26 Issue:2 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sharma Lokesh¹^ORCID,Peng Xiaohua¹²,Qing Hua³⁴,Hilliard Brandon K.³⁴,Kim Jooyoung¹,Swaminathan Anush³⁴,Tian Justin³⁴,Israni-Winger Kavita³⁴,Zhang Cuiling³⁴,Habet Victoria⁵,Wang Lin¹,Gupta Gayatri¹,Tian Xuefei⁶,Ma Yina⁷,Shin Hyeon-Jun¹,Kim Sang-Hun¹,Kang Min-Jong¹,Ishibe Shuta⁶,Young Lawrence H.⁷,Kotenko Sergei⁸,Compton Susan⁹,Wilen Craig B.⁴¹⁰^ORCID,Wang Andrew³⁴,Dela Cruz Charles S.¹¹¹¹²

Affiliation:

1. Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA

2. Department of Rehabilitation Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

3. Section of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA

4. Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA

5. Section of Pediatric Critical Care Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA

6. Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA

7. Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA

8. Department of Biochemistry and Molecular Biology, Rutgers New Jersey Medical School, New Brunswick, New Jersey, USA

9. Molecular and Serological Diagnostics, Department of Comparative Medicine, Yale School of Medicine, New Haven, Connecticut, USA

10. Department of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, USA

11. Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA

12. Veterans Affairs Medical Center, West Haven, Connecticut, USA

Abstract

The antiviral and pathological potential of type I and type III interferons during coronavirus infection remains poorly defined, and opposite findings have been reported. We report that both type I and type III interferons have anticoronaviral activities, but their potency and organ specificity differ.

Funder

American Lung Association

Francis Family Foundation

HHS | National Institutes of Health

Pew Charitable Trusts

U.S. Department of Defense

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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